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(B) Representative DIC images of scores from the RNAi screen for genes rendering metformin resistance at 150 mM (highlighted with green boxes) and metformin sensitivity at 25 mM (highlighted with red boxes). By compare, immunostaining for FosB and its truncated connection variable FosB, both of which organize a longer half-life than c-fos and amass during repeated or long- lasting stimulation, are increased in several hypothalamic nuclei and stretch out to the amygdala and hippocampus?
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Treatment includes eliciting a clinically significant response without excessive levels of side effects?